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IL-23 induces CLEC5A+ IL-17A+ neutrophils and elicit skin inflammation associated with psoriatic arthritis
Furuya H, Nguyen CT, Chan T, Marusina AI, Merleev AA, Garcia-Hernandez M, Hsieh S, Tsokos GC, Ritchlin CT, Tagkopoulos I, Maverakis E, Adamopoulos IE |
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Innate immune memory in rheumatic diseases
Jeljeli M and Adamopoulos IE*. Nature Reviews Rheumatology 2023 (Invited Review-Accepted) |
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IL-17A and IL-17F in tissue homeostasis, inflammation and regeneration
Adamopoulos IE , Kuchroo V. Nature Reviews Rheumatology 2023 (Jul 24. doi: 10.1038/s41584-023-01004-5. Online ahead of print). |
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IL-27 attenuates IL-23 mediated inflammatory arthritis
R Sarin, R Gu, Z Jalali, E Maverakis, MG Tsokos and IE Adamopoulos*. Clinical Immunology 2023. (Apr 8:109327. doi: 10.1016/j.clim.2023.109327. Online ahead of print). |
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Autophagy Pathways in Autoimmune Diseases
Keller CW, Adamopoulos IE, Lünemann JD. Journal of Autoimmunity 2023. (Apr;136:103030. doi: 10.1016/j.jaut.2023.103030. Epub 2023 Mar 29). (Editor's Choice) |
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Interleukin-23 Regulates Inflammatory Osteoclastogenesis via Activation of CLEC5A(+) Osteoclast Precursors
Furuya H, Nguyen CT, Hsieh S, Gu R, Maverakis E, Adamopoulos IE*. Arthritis and Rheumatology 2023, Aug;75(8):1477-1489. doi: 10.1002/art.42478. Epub 2023 Jun 6. (COVER IMAGE) |
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Peripheral γδ T Cells Regulate Neutrophil Expansion and Recruitment in Experimental Psoriatic Arthritis
Nguyen CT, Furuya H , Das D, Marusina AI, Merleev AA, Ravindran R, Jalali R, Khan IH, Maverakis E, Adamopoulos IE. Arthritis and Rheumatology . 2022 Sep;74(9):1524-1534. doi: 10.1002/art.42124. Epub 2022 Jul 21. |
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Interleukin-23 reshapes kidney resident cell metabolism and promotes local kidney inflammation
Li H, Tsokos MG, Bhargava R, Adamopoulos IE, Menn-Josephy H, Stillman IE, Rosenstiel P, Jordan J, Tsokos GC. J Clin Invest. 2021 May 6:142428. doi: 10.1172/JCI142428. |
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IL-23 inhibition in ankylosing spondylitis: where did it go wrong?
Baeten D and Adamopoulos IE. Frontiers in Immunology 2021 Feb 18;11:623874. |
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Interleukin-17 and Interleukin-23: A Narrative Review of Mechanisms of Action in Psoriasis and Associated Comorbidities
Menter A, Krueger GG, Paek SY, Kivelevitch D, Adamopoulos IE, Langley RG. Dermatol Ther (Heidelb). 2021 Jan 29. doi: 10.1007/s13555-021-00483-2 |
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Psoriatic arthritis; Overcoming the challenges by creating opportunities
Bell S, Nahle Z and Adamopoulos IE. Clinical Immunology 2020 Sep;218:108519.doi:10.1016/j.clim.2020 .108519. |
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A site-specific map of the human plasma glycome and its age and gender associated alterations
Merleev AA, Kailemia MJ, Xu G, Park D, Ruhaak LR, Kim K, Hong Q, Patel F, Stroble C, Gershwin EM, Wan Y, Bowlus C, Marusina AI, Adamopoulos IE, Lal N, Shimoda M, Luxardi G, Lebrilla CB, and Maverakis E. Sci Rep. 2020 Oct 15;10(1):17505. doi: 10.1038/s41598-020-73588. |
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Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th edition)
Klionsky DJ, Abel S, Adamopoulos IE, Agnello M, et al. Autophagy DOI: 10.1080/15548627.2020.1797280 Bromodomain-containing-protein-4 and Cyclin-Dependent-Kinase-9 Inhibitors Synergistically Reduces the severity of Post-Traumatic Osteoarthritis Fukui T, Yik J, Doyran B, Davis J, Haudenschild AK, Adamopoulos IE, Han L, Haudenschild DR*. Osteoarthritis and Cartilage 2020 Oct 23:S1063-4584(20)31157-2. doi: 10.1016/j.joca.2020.07.012 New Dimensions in the Diagnosis, Science and Management of Axial Spondyloarthritis Ritchlin CT* and Adamopoulos IE. The British Medical Journal (BMJ. 2021 Jan 4;372:m4447. doi: 10.1136/bmj.m4447. Psoriatic arthritis under the influence of IFNγ Dai D, and Adamopoulos IE*. Clinical Immunology 2020 Jun 20:108513. doi: 10.1016/j.clim.2020.108513. Online ahead of print. Systemic lupus erythematosus favors the generation of IL-17 producing double negative T cells Li H, Adamopoulos IE, Moulton VR, Stillman IE, Herbert Z, Moon J, Sharabi A, Krishfield S, Tsokos MG, Tsokos GC. Nature Communications 2020 Jun 5;11(1):2859. Go with the flow: Vascular passages in bone Ritchlin CT and Adamopoulos IE. Nature Metabolism 2019; 1: 173–174 γδ T cells in rheumatic diseases: from fundamental mechanisms to autoimmunity Nguyen C, Maverakis E, Eberl M, Adamopoulos IE*. Seminars in Immunopathology 2019 Sep;41(5):595-605. Editorial: IL-17A and new bone formation: The myth of Prometheus revisited Adamopoulos IE*. Arthritis and Rheumatology 2019 Apr;71(4):483-485. 2D Visualization of the psoriasis transcriptome via nonlinear dimensionality reduction fails to support the notion of dual-secreting IL-17A IL-22 Th17 T cells Le S, Merleev AA, Luxardi G, Shimoda M, Tsoi LC, Wang J, Alexanian C, Raychaudhuri S, Adamopoulos IE, Gudjonsson J, Marusina A, Maverakis E. Frontiers in Immunology 2019 Apr 4;10:589. doi: 10.3389/fimmu.2019.00589. Compendium of Synovial Signatures Identifies Pathologic Characteristics for Predicting Treatment Response in Rheumatoid Arthritis Patients Kim K, Kim M, Adamopoulos IE, Tagkopoulos I. Clinical Immunology 2019 May;202:1-10. Meta-analysis of RNA sequencing datasets reveals an association between TRAJ23, psoriasis, and IL-17A Merleev AA, Marusina AI, Ma C,Elder JT, Tsoi LC, Raychauduri SP, Weidinger S, Wang EA, Adamopoulos IE, Luxardi G, Gudjonsson JE, Shimoda M, Maverakis E. JCI Insight 2018 Jul 12;3(13). γδTCR regulates production of interleukin-27 by neutrophils and attenuates inflammatory arthritis Bouchareychas L, Kang M, Grössinger EM, Adamopoulos IE*. Scientific Reports 2018 May 15;8(1):7590. doi: 10.1038/s41598-018-25988-3. Pathophysiology and inhibition of IL-23 signaling in psoriatic arthritis: A molecular insight Nguyen C, Bloch Y, Skladanowska K, Savvides SN, Adamopoulos IE*. Clinical Immunology 2018 Sep;206:15-22 Structural activation of pro-inflammatory human IL-23 by its cognate receptor IL-23R Bloch Y, Bouchareychas L, Merceron R, Składanowska K, Bossche LV, Detry S, Govindarajan S, Elewaut D, Haerynck F, Dullaers M, Adamopoulos IE, Savvides SN. Immunity 2018 Jan 16;48(1):45-58 Ca2+-dependent regulation of NFATc1 via KCa3.1 in Inflammatory Osteoclastogenesis Grössinger EM, Bouchareychas L, Kang M, Sarin R, Haudenschild DR, Borodinsky LN, Adamopoulos IE*. Journal of Immunology 2018 Jan 15;200(2):749-757 Inflammation in bone physiology and pathology Adamopoulos IE*. Current Opin Rheumatol 2018 Jan 30(1):59-64 Targeting IL-17 in Psoriatic Arthritis A. Wang, E Suzuki, E Maverakis and IE Adamopoulos*. European Journal of Rheumatology 2017 4:272-277. DOI 10.51.52 Loss of WDFY3 Ameliorates Severity of Serum Transfer-induced Arthritis independently of Autophagy DJ Wu and IE Adamopoulos*. Cellular Immunology 2017 Jun;316:61-69. Concise review: Stem cells in Osteoimmunology F. Fiero, J. Nolta, IE Adamopoulos*. Stem cells 2017 Jun;35(6):1461-1467. Autophagy and autoimmunity DJ Wu and IE Adamopoulos*. Clinical Immunology 2017 Jan 15;176:55-62. Critical role of LTB4/BLT1 in IL-23 induced synovial inflammation and osteoclastogenesis via NFκB L Bouchareychas, E Grössinger, M Kang, H Qiu, IE Adamopoulos*. Journal of Immunology 2017 Jan 1;198(1):452-460 CD4+ Virtual Memory: Antigen-inexperienced T cells reside in the naive, regulatory, and memory T cell compartments at similar frequencies, implications for autoimmunity AI Marusina, Y Ono, AA Merleev, M Shimoda, H Ogawa, EA. Wang, K Kondo, L Olney, G Luxardi, Y Miyamura, TD. Yilma, I Bustos-Villalobos, JW Bergstrom, DG Kronenberg, AM. Soulika, IE Adamopoulos and E Maverakis. J Autoimmun. 2016 Nov 25. pii: S0896-8411(16)30241-4. NETosis and selective autophagy-linked FYVE protein Wdfy3 are critical for IL-17A-mediated epidermal hyperplasia E Suzuki, E Maverakis, R Sarin, L. Bouchareychas, V Kuchroo, FO Nestle, IE Adamopoulos*. Journal of Immunology. 2016 Dec 1;197(11):4403-4412 Autophagy-linked FYVE containing protein WDFY3 interacts with TRAF6 and modulates RANKL-induced osteoclastogenesis DJ Wu, R Gu, R Sarin, R Zavodovskaya, CP Chen, BA Christiansen, IE Adamopoulos*. J.Autoimmun. 2016 Sep;73:73-84. Interactions of the immune system with skin and bone tissue in psoriatic arthritis: A Comprehensive Review A Sukhov, IE Adamopoulos and EM Maverakis. Clinical reviews in Allergy and Immunology 2016 Aug;51(1):87-99. Toll Like Receptors: from microbial recognition to autoimmune arthritis M. Jimenez-Dalmaroni, ME Gershwin and IE Adamopoulos*. Autoimmunity Reviews 2015 S1568-9972(15)00184-6. doi: 10.1016/j.autrev.2015.08.009. [Epub ahead of print]. Paper was chosen for the “Highlighted research” series. IL-17A induces bone destruction and epidermal hyperplasia associated with psoriatic arthritis *IE Adamopoulos, Suzuki E, Chao CC, Gorman D, Adda S, Maverakis E, Zarbalis K, Geissler R, Asio A, Blumenschein WM, McClanahan T, de Waal Malefyt R, Gershwin ME, EP Bowman. Annals of Rheumatic Diseases 2015 Jun 74(6):1284-92 doi: 10.1136/annrheumdis-2013-204782. Autoimmune or Autoinflammatory? Bad to the Bone *IE Adamopoulos. International Journal of Clinical Rheumatology. 2015 10:1;5-7 (Invited Editorial). Arthritis: Alternative Pathways of Osteoclast Differentiation in Inflammatory Arthritis *IE Adamopoulos and ED Mellins. Nature Rheumatology Reviews 2015 Mar;11(3):189-194 (doi: 10.1038/ PMID: 25422000). Crosstalk among IL-23, MDL-1 and DAP12-dependent pathways promotes bone destruction in inflammatory arthritis HS Shin, R Sarin, N Dixit, J Wu, ME Gershwin, EP Bowman and *IE Adamopoulos. Journal of Immunology 2015 Jan 1;194(1):316-24. Anti-Kelch-like 12 and Anti-Hexokinase 1 Autoantibodies in Primary Biliary Cirrhosis: Closing the Window Further on "AMA-negative PBC" GL Norman, CY Yang, HP Ostendorff, Z Shums, MJ Lim, J Wang, G Hirshfield, P Milkiewicz, DB. Bloch, CL Bowlus, IE Adamopoulos, PSC. Leung, and ME. Gershwin. Liver International 2015 Feb;35(2):642-51 . Interleukin 23 induces osteoclastogenesis via a Leukotriene B4 dependent pathway N Dixit, D Wu, YH Belgacem, LN Borodinsky and *IE Adamopoulos. Arthritis Research and Therapy 2014 Dec 2;16(6):496. Loss of Wdfy3 in mice results in abnormal cortical neurogenesis reflecting aspects of the autism pathology LA Orosco, SL Cates, AP Ross, J Sohn, D Pleasure, SJ Pleasure, IE Adamopoulos, KS Zarbalis. Nature Communications 2014 Sep 8;5:4692. doi: 10.1038/ncomms5692. The role of IL-23/IL-17 axis in psoriatic arthritis E Suzuki, ED Mellins, ME Gershwin, FO Nestle, *IE Adamopoulos. Autoimmunity Reviews 2014;13(4-5):496-502. A novel in vivo gene transfer technique and in vitro cell based assays for the study of bone loss in musculoskeletal disorders DJ Wu, N Dixit, T. Nguyen, E Suzuki, HS Shin, J. Davis, E. Maverakis, *IE Adamopoulos. Journal of Visualized Experiments 2014 e51810, doi:10.3791/51810. NKG2C, HLA-E and their association with psoriasis F Patel, C Duong, IE Adamopoulos, E Maverakis. Experimental Dermatology 2013 Dec;22(12):797-9. A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting A Ross, MA Mansilla, Y Choe, RL Maute, SR May, KK. Hozyasz, P Wójcicki, A Mostowska, B Davidson, IE Adamopoulos, A Peterson, SJ Pleasure, JC. Murray, KS Zarbalis* PLoS One 2013 Jul 25;8(7):e69333. doi: 10.1371/journal.pone.0069333. The Implication of Vitamin D and Autoimmunity: a Comprehensive Review CY Yang, PS Leung, IE Adamopoulos, ME Gershwin. Clin Rev Allergy Immunol. 2013 Oct;45(2):217-26. The emerging role of IL-27 in bone destruction and inflammatory arthritis *IE Adamopoulos and S Pflanz. Cytokines and Growth Factors Reviews 2013 Apr;24(2):115-21 (Invited Review). Rheumatoid and pyrophosphate arthritis synovial fibroblasts induce osteoclastogenesis independently of RANKL, TNF and IL-6 TJ Dickerson, E Suzuki, C Stanecki, HS, Shin, H Qui and IE Adamopoulos* Journal of Autoimmunity 2012 Dec;39(4):369-76.** Paper was highlighted by Nature Reviews Rheumatology: Bone: An alternative pathway for bone destruction in inflammatory arthritis? Ray K. Nat Rev Rheumatol. 2012 Oct;8(10):563. IL-23 is critical for the induction of arthritis, osteoclast formation and maintenance of bone mass (*) *IE Adamopoulos, M Tessmer, CC Chao, S Adda, D Gorman, M Petro, CC Chu, RH Pierce, W Yao, NE Lane, D Laface, *EP Bowman. Journal of Immunology 2011 15:187(2):951-9. Paper was highlighted by Pap T and Heitzmann M: F1000 Prime Recommendation In F1000Prime, 27 Jul 2011; and by ASBMR web scientific editor Joe Lorenzo. Anti-IL-17A therapy protects against bone erosion in experimental models of rheumatoid arthritis CC Chao, SJ Chen, IE Adamopoulos, N Davis, K Hong, A Vu, S Kwan, L Fayadat-Dilman, A Asio, EP Bowman. Autoimmunity 2011 May 44(3):243-52. Myeloid DAP12- associating lectin (MDL)-1 receptor regulates synovial inflammation and bone erosion associated with autoimmune arthritis B Joyce-Shaikh, M Bigler, CC Chao, E Murphy, IE Adamopoulos, P Heyworth, E Bowman, T McClanahan, J. Phillips and DJ Cua*. Journal of Experimental Medicine 2010 Mar 15;207(3):579-89. Structural, cellular, and molecular evaluation of bone erosion in experimental arthritis models: assessment by μCT, histology, and serum biomarkers CC Chao, SJ Chen, IE Adamopoulos, EP Bowman. Autoimmunity 2010 Dec;43(8):642-53. IL-17A upregulates RANK on osteoclast precursors *IE Adamopoulos, CC Chao, R Geissler, DM Laface, W Blumenschein, T McClanahan and EP Bowman. Arthritis Research and Therapy 2010 Feb 18;12(1):R29. Immune regulation of bone loss by Th17 cells *IE Adamopoulos and EP Bowman. Arthritis Research and Therapy 2008;10(5):225. Fine mapping of the MHC Class III region demonstrates association of AIF1 and rheumatoid arthritis SJ Harney, C Vilariño-Güell, IE Adamopoulos, AM Sims, RW Lawrence, LR Cardon, JL Newton, C Meisel, JJ Pointon, C Darke, NA Athanasou, BP Wordsworth, MA Brown. Rheumatology (Oxford) 2008;47(12):1761-7. Cellular and humoral mechanisms of osteoclast formation in Ewing’s Sarcoma Lau, IE Adamopoulos, H Giele, CLMH Gibbons, NA Athanasou. British Journal of Cancer 2007;96(11):1716-22. Quantification of bone resorption in experimental model of arthritis by a novel software “Osteo-Pro” *IE Adamopoulos and K Pataridis. Journal of Computational Methods in Science and Engineering 2007;7(2):87-91. Hepatocyte growth factor can substitute for M-CSF to support osteoclastogenesis *IE Adamopoulos, Z Xia, YS Lau, NA Athanasou. Biochemical and Biophysical research communications 2006;350(2):478-83. Macrophage-mediated biodegradation of Poly (DL-lactide-co-glycolide) in vitro Z Xia, Y Huang, A Walpole, IE Adamopoulos, J Triffitt, Z Cui. Journal of Biomedical Materials Part A 2006;79(3):582-90. Osteoclast differentiation and bone resorption in multicentric reticulohistiocytosis IE Adamopoulos, BP Wordsworth, JR Edwards, DJ Ferguson, NA Athanasou. Human Pathology 2006;37(9):1176-85. Stimulation of osteoclast formation and resorption by inflammatory arthritis synovial fluid IE Adamopoulos, L Danks, I Itonaga, R Locklin, A Sabokbar, DJ Ferguson, NA Athanasou. Virchows Archives 2006;449(1):69-77. In vitro biodegradation of three brushite calcium phosphate cements by a macrophage cell-line Z Xia, LM Grover, Y Huang, IE Adamopoulos, U Gbureck, JT Triffitt, RM Shelton, JE Barralet. Biomaterials 2006;27(26):4557-65. LIGHT (TNFSF14), a novel mediator of bone resorption, is elevated in rheumatoid arthritis JR Edwards, S Sun, R Locklin, C Shipman, IE Adamopoulos, NA Athanasou, A Sabokbar. Arthritis and Rheumatism 2006;54(5):1451-1462. Hepatocyte growth factor in normal and diseased bone and joint tissues *IE Adamopoulos and NA Athanasou. Current Rheumatology Reviews 2006;2(1):1-7. Synovial fluid macrophages are capable of osteoclast formation and resorption IE Adamopoulos, A Sabokbar, BP Wordsworth, A Carr, DJ Ferguson, NA Athanasou. Journal of Pathology 2006;208(1):35-43. |